|
(from UDaily
6/15/2007)
|
Project Overview The scientific goal of this COBRE proposal is to
create the infrastructure and expertise base to address the mechanisms of OA,
as well as its prevention and treatment. We propose to develop
multidisciplinary research in the field of osteoarthritis (OA), from the lab
bench to the clinic, with a unique focus on mentoring Women In Science and
Engineering (WISE). In this proposal, each of the five projects is lead by a
women faculty member. The uniqueness
of the approach to be employed by our center will be the examination of OA
from the integrated perspectives of tissue mechanics, biomechanics, physical
therapy and clinical intervention. Five
projects will be carried out under the Center umbrella. They span the
continuum from tissue engineering to clinical evaluation. The project
participants are drawn from multiple academic units in the Colleges of
Engineering, Arts & Sciences, and Health Sciences. Each project has
faculty from multiple departments working together as a multidisciplinary
team. (PI: Thomas Buchanan)
Individual projects are:
- Perlecan and Heparanase in Cartilage Growth and Healing (PI: Catherine Kirn-Safran)
- Solute Transport in the Subchondral Bone Plate of Osteoarthritic Joints (PI: Liyun Wang)
- Risk Factors for Progression of Osteoarthritis
of the Knee (PI: Jill Higginson)
- Joint Loading and the Progression of
Osteoarthritis following Total Knee Arthroplasty (PI:
Lynn Snyder-Mackler)
- Knee Stiffness, Proprioception
and Instability affect Knee Control in OA (PI: Katy Rudolph)
|