Research

We are currently conducting a variety of collaborative research projects supported by the National Institutes of Health and other funding sources.

COBRE III for Women in Science and Engineering on Osteoarthritis (NIH)
PI: Thomas Buchanan
Collaborators: Jill Higginson, Liyun Wang, Randall Duncan, Catherine Kirn-Safran, Lynn Snyder Mackler, Anja Nohe, Chris Kloxin
AbstractThree core resources will be
run through this award: (1) A cytomechanics core, first established in our phase II grant, will be strengthened to provide tools for orthopaedic researchers to study how bone, cartilage and ligament respond to stress and strain. This involves tools for bioimaging and micromechanical testing. (2) A patient specific modeling (PSM)
core will be established. This is a modification and expansion of the motion analysis core established in our COBRE I award. It will provide a means to determine differences in tissue forces associated with pathologies and will also be used to determine biomechanical differences associated with various treatment paths, which may impact the development of osteoarthritis. (3) A clinical research core (the ResCore) will be established for the first time to aid us as we expand our clinical trials. It will provide patient database access and
biostatistics support for all projects.

Robotic Exoskeletons, FES, and Biomechanics: Treating Movement Disorders (NIH)
PI: Jill Higginson
Collaborators: Stuart Binder-Macleod
Abstract: This renewal application builds upon the success of our team in developing novel un-motorized and motorized exoskeletons and Functional Electric Stimulation (FES) systems for gait training of stroke and other motor-impaired patients. 

Solute Transport in the Bone Lacunar- Canalicular System (NIH)
PI: Liyun Wang
Collaborators: Randall Duncan
Abstract: This proposed research will delineate the transport mechanisms that are essential  
for osteocyte viability and bone mechanotransduction, and provide new insights
into mass transport in other biological and engineered systems such as tissue
engineering scaffolds.